Table 3.
Association analysis of SNPs (−592, -819, -1082, -1352) in the promoter region of the IL-10 gene, in Squamous Intraepithelial Cervical Lesions (SICL)
|
(−592 C/A) (rs1800872) |
(−819 C/T) (rs1800871) |
||||||
|---|---|---|---|---|---|---|---|
| Genotype | n(%)SICL/(%)NCL (n = 204/166) | ORa (IC95%) | p Value* | Genotype | n(%)SICL/(%)NCL (n = 204/166) | ORa (IC95%) | p Value* |
|
Codominant Model |
Codominant Model |
||||||
| C/C |
50(24.5)/66(40) |
1 |
C/C |
64(31.4)/57(34.3) |
1 |
||
| C/A |
105(52)/70(42) |
2.0(1.21-3.32) |
0.007 |
C/T |
94(46)/75(45.2) |
1.16(0.71-1.92) |
0.53 |
| A/A |
49(24)/30(18) |
2.07(1.10-3.89) |
0.02 |
T/T |
46(22.6)/34(20.5) |
1.15(0.62-2.12) |
0.64 |
|
Dominant Model |
Dominant Model |
||||||
| C/C |
50(24.5)/66(40) |
1 |
C/C |
64(31.4)/57(34.3) |
1 |
||
| C/A + A/A |
154(76)/100(60) |
2.02(1.26-3.25) |
0.003 |
C/T + T/T |
140(68.5)/109(65.7) |
1.16(0.73-1.84) |
0.51 |
|
Recessive Model |
Recessive Model |
||||||
| C/C + C/A |
155(76)/136(82) |
1 |
C/C + C/T |
158(77.4)/132(79.5) |
1 |
||
| A/A |
49(24)/30(18) |
1.37(0.79-2.39) |
0.25 |
T/T |
46(22.6)/34(20.5) |
1.05(0.61-1.81) |
0.84 |
|
Alleles |
Alleles |
||||||
| C |
205(51)/202(60) |
1 |
C |
222(54)/189(57) |
1 |
||
| A |
203(49)/130(40) |
1.32 (0.97-1.81) |
0.07 |
T |
186(46)/143(43) |
1.10(0.80-1.50) |
0.53 |
|
p HWE** |
0.13 |
p HWE** |
0.31 |
||||
|
(−1082 A/G) (rs1800872) |
(−1352 G/A) (rs1800893) |
||||||
|
Genotype |
n(%)SICL/(%)NCL (n = 204/166) |
ORa (IC95%) |
p Value* |
Genotype |
n(%)SICL/(%)NCL (n = 204/166) |
ORa (IC95%) |
p Value* |
|
Codominant Model |
Codominant Model |
||||||
| A/A |
125(61.3)/92(55.4) |
1 |
G/G |
130(63.72)/102(61.44) |
1 |
||
| A/G |
66(32.3)/62(37.3) |
0.95(0.59-1.52) |
0.84 |
G/A |
64(31.37)/53(31.94) |
1.28(0.78-2.07) |
0.31 |
| G/G |
13(6.4/12(7.3) |
1.02(0.42-2.44) |
0.96 |
A/A |
10(4.9)/11(6.62) |
0.85(0.33-2.22) |
0.75 |
|
Dominant Model |
Dominant Model |
||||||
| A/A |
125(61.3)/92(55.4) |
1 |
G/G |
130(63.72)/102(61.44) |
1 |
||
| A/G + G/G |
79(38.7)/74(44.6) |
0.96(0.61-1.50) |
0.87 |
G/A + A/A |
74(36.27)/64(38.56) |
1.20(0.76-1.90) |
0.42 |
|
Recessive Model |
Recessive Model |
||||||
| A/A + A/G |
191(93.6)/154(92.7) |
1 |
G/G + G/A |
194(95)/155(93.38) |
1 |
||
| G/G |
13(6.4/12(7.3) |
1.04(0.44-2.44) |
0.92 |
A/A |
10(4.9)/11(6.62) |
0.78(0.30-1.99) |
0.6 |
|
Alleles |
Alleles |
||||||
| A |
316(77)/246(74) |
1 |
G |
324(79)/257(77) |
1 |
||
| G |
92(23)/86(26) |
1.01(0.71-1.45) |
0.92 |
A |
84(21)/75(23) |
1.08(0.74-1.58) |
0.65 |
| p HWE** | 0.72 | p HWE** | 0.26 | ||||
a. Odds ratio adjusted by age and HPV genotype.
** Hardy-Weinberg Equilibrium in controls (NCL).
*p Value < = 0.01 adjusted by Bonferroni.