Table 2.
Family-based association analyses for anti-Plasmodium falciparum IgG levels
| Locus | SNP ID number | Allelea(AFb) | Pc |
|---|---|---|---|
|
IL12Bpro (promoter) |
rs17860508 |
TTAGAG/GC (0.3068) |
P > 0.05 |
|
IL12B (3'UTR) |
rs3212227 |
A/C (0.3275) |
P > 0.05 |
|
IL4-590 (promoter) |
rs2243250 |
C/T (0.8017) |
P > 0.05 |
|
FCGR2A H/R131 (exon 4) |
rs1801274 |
C/T (0.5371) |
Td (0.0166f) |
|
HbC (exon1) |
rs33930165 |
A/C (0.1682) |
Cd(0.0091e,g) |
|
HbS (exon1) |
rs334 |
A/T (0.0193) |
P > 0.05 |
|
LTA + 80 (intron 1) |
rs2239704 |
C/A (0.3542) |
P > 0.05 |
|
TNF-1031(promoter) |
rs1799964 |
T/C (0.1106) |
P > 0.05 |
|
TNF-863 (promoter) |
rs1800630 |
C/A (0.0858) |
Ad (0.0440e) |
|
TNF-857 (promoter) |
rs1799724 |
C/T (0.0228) |
Td(0.0064e,g) |
|
TNF-308 (promoter) |
rs1800629 |
G/A (0.1063) |
P > 0.05 |
|
TNF-238 (promoter) |
rs361525 |
G/A (0.0264) |
P > 0.05 |
|
TNF1304 (intron 3) |
rs3093664 |
A/G (0.075) |
Ad(0.0083e,g) |
|
NCR3-412 (promoter) |
rs27362191 |
G/C (0.2267) |
P > 0.05 |
| NCR3*3790 (3'UTR) | rs986475 | T/C (0.0272) | Cd (0.0307e) |
Abbreviations: HbC, Haemoglobin C; IL4, Interleukin 4; LTA, Lymphotoxin-α; AF, allele frequency; NCR3, Natural cytotoxicity receptor 3; SNP, Single-nucleotide polymorphism; TNF, Tumour necrosis factor; UTR, Untranslated region.
aWild allele / variant allele.
bVariant allele frequency that was calculated in the study population.
cChi-square test P-value for IgG levels.
dAllele positively associated.
eAdditive model.
fDominant model.
gSignificant P value after applying a false discovery rate of 10%.