Table 3.
Family-based association analyses for anti-Plasmodium falciparum IgG subclass levels
| IgG1 | IgG2 | IgG3 | IgG4 | |
|---|---|---|---|---|
| Locus |
Pa |
Pa |
Pa |
Pa |
|
IL12Bpro |
P > 0.05 |
P > 0.05 |
P > 0.05 |
P > 0.05 |
|
IL12B3’UTR |
P > 0.05 |
P > 0.05 |
P > 0.05 |
P > 0.05 |
|
IL4-590 |
P > 0.05 |
P > 0.05 |
Cb (0.0472d) |
P > 0.05 |
|
FCGR2A H/R131 |
P > 0.05 |
Tb(0.0003e,f) |
Cb(0.0010d,f) |
P > 0.05 |
|
HbC |
P > 0.05 |
Cb (0.0139d) |
P > 0.05 |
P > 0.05 |
|
HbS |
P > 0.05 |
P > 0.05 |
P > 0.05 |
P > 0.05 |
|
LTA + 80 |
Ab (0.0305c) |
Ab (0.0505c) |
Ab (0.0214c) |
Ab (0.0139c) |
|
TNF-1031 |
P > 0.05 |
P > 0.05 |
P > 0.05 |
P > 0.05 |
|
TNF-863 |
Ab (0.0379c) |
P > 0.05 |
Ab(0.0082c,f) |
P > 0.05 |
|
TNF-857 |
P > 0.05 |
P > 0.05 |
Tb (0.0413c) |
Tb (0.0249c) |
|
TNF-308 |
P > 0.05 |
P > 0.05 |
P > 0.05 |
P > 0.05 |
|
TNF-238 |
P > 0.05 |
P > 0.05 |
P > 0.05 |
P > 0.05 |
|
TNF1304 |
Ab (0.0495c) |
P > 0.05 |
Ab(0.0099c,f) |
Ab(0.0108c,f) |
|
NCR3-412 |
P > 0.05 |
P > 0.05 |
P > 0.05 |
P > 0.05 |
| NCR3*3790 | P > 0.05 | P > 0.05 | Cb (0.0276c) | Cb (0.0196c) |
Abbreviations: HbC, Haemoglobin C; IgG, Immunoglobulin G; IL4, Interleukin 4; LTA, Lymphotoxin-α; NCR3, Natural cytotoxicity receptor 3; P. falciparum, Plasmodium falciparum; TNF, Tumour necrosis factor.
aChi-square test P-value.
bAllele positively associated.
cAdditive model.
dDominant model.
eRecessive model.
fSignificant P value after applying a false discovery rate of 10%.