Table 6.
Serum calcium and urinary calcium:creatinine following single-dose vitamin D3 (70,000 IU) in pregnant participants
| |
|
Total serum calcium conc. (mmol/L) |
Albumin-adjusted serum calcium concentration (mmol/L) |
Urine calcium:creatinine ratio (mmol/mmol) |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Follow-up time | Na | Mean (SD) | Mean (SD) | Range | # > 2.60 | Na | Meanb | Median (IQR) | Range | # > 1.0 |
| 0 days |
27 |
2.29 (0.08) |
2.40 (0.05) |
2.25 to 2.5 |
0 |
27 |
0.14 |
0.20 (0.32) |
0.01 to 0.69 |
0 |
| 2 days |
13 |
2.31 (0.09) |
2.43 (0.07) |
2.27 to 2.51 |
0 |
– |
– |
– |
– |
– |
| 4 days |
13 |
2.30 (0.08) |
2.43 (0.06) |
2.32 to 2.56 |
0 |
– |
– |
– |
– |
– |
| 2nd to 4th week (days 7 to 27) |
27 |
2.30 (0.10) |
2.43 (0.09) c |
2.24 to 2.57 |
0 |
33 |
0.33 d |
0.31 (0.31) |
0.06 to 1.05 |
3 |
| 5th to 8th week (days 28 to 55) |
20 |
2.29 (0.07) |
2.43 (0.05) |
2.34 to 2.51 |
0 |
35 |
0.31d |
0.41 (0.31) |
0.05 to 1.48 |
4 |
| 9th to 11th week (days 56 to 76) |
14 |
2.39 (0.11) |
2.46 (0.06) |
2.37 to 2.61 |
1 |
28 |
0.33 d |
0.36 (0.36) |
0 to 1.74 |
2 |
| Total |
114 |
2.31 (0.09) |
2.42 (0.07) |
2.24 to 2.61 |
1 |
123 |
0.24 |
0.33 (0.36) |
0 to 1.74 |
9 |
| |
N |
Mean (SD) |
Mean (SD) |
Range |
# > 3.00 |
|
|
|
|
|
| Cord Blood | 12 | 2.57 (0.23) | 2.68 (0.16) | 2.28 to 2.9 | 0 | – | – | – | – | – |
a. Number of specimens (there may have been multiple specimens from a single participant during a given follow-up period).
b. Geometric means.
c. Mean at day 7 was higher than baseline (+0.05; 95% CI, 0.01 to 0.08), which remained statistically significant after correcting for multiple testing.
d. Means at days 7, 14, 21, 28, 35, 56, and 63 were significantly higher than baseline, after correcting for multiple testing.