Figure 5. Evidence for trans-regulation by LIGHT and lack of a role of liver non-parenchymal cells.

(A) HL mRNA expression in hepatocytes from LDLR^−/− (WT) and LTβR^−/−LDLR^−/− mice cocultured with Ad-LIGHT (Ad-L) or Ad-Null (Ad-N) infected FL83B cells. (B) HL mRNA expression in hepatocytes from LTβR^−/−LDLR^−/− mice cocultured with Ad-N or Ad-L infected FL83B cells and Tg-LIGHT mouse liver non-parenchymal cells (NPC). (n = 3; *<0.05 vs. Ad-N infected FL83B coculture).