Figure 2. The L2-IL-1β mouse model of Barrett esophagus (BE) and esophageal adenocarcinoma (EAC). (A) Histological appearance of BE lesions, consisting of columnar mucosa and mucus-producing cells at the squamocolumnar junction (SCJ) in the L2-IL-1β mouse. (B) Anatomical differences between human and mouse stomach. The SCJ is distal to the esophago-gastric junction and comprises the border between the squamous forestomach and the columnar-lined stomach in the mouse. In the figure on the far right, the mouse stomach has been opened along the greater curvature to demonstrate the location of the SCJ. The vertical line demonstrates the location of the sagittal section seen in Figure 2A. (with kind permission from Cancer Cell / Elsevier, Quante, Bhagat et al. 2012) (C) Human Barrett esophagus, containing columnar cells and goblet cells. (D) Electron microscopic appearance of mouse BE lesions demonstrating columnar appearance, mucin granules, and surface microvilli. (E) Tumor at the SCJ seen during upper endoscopy of an L2-IL-1β mouse. (F) Macroscopic appearance of tumor at the SCJ in the L2-IL-1β mouse.