Figure 1. Presence of a defect in karyokinesis during endomitosis. (A)I–III: Until anaphase, lamin immunostaining shows that the nuclear membrane of endomitotic MK remains disassembled. IV–VI: At late telophase, the nuclear membrane starts to reassemble. IV–IX: The nuclear membrane is not complete at the end of endomitosis. White arrows, Lamin between segregated chromosomes; yellow arrow, one control cell not in mitosis. (B) A typical polyploid MK, which possesses a single polylobulated nucleus after endomitosis. I, TOTO; II, lamin A/C; III, lamin A/C (green) and TOTO (blue); white arrows, DNA and lamin link between segregated chromosomes.