Table 1.
Significantly (p<0.0001) different mass peaks between benign and malignant cyst fluid samples, with ROC AUC >0.70 are listed with m/z value and identified peaks
| Protein | Fraction | Peak m/z value | Mean intensity benign/malignant | ROC AUC | Specificity % (CI) |
|---|---|---|---|---|---|
|
PCI |
EB-E3 |
3902 |
30.23 / 7.00 |
0.79 |
67.7 (58.9-75.6) |
|
ApoC-III |
EB-E3 |
9743 |
3.60 / 15.09 |
0.82 |
68.5 (59.7-76.3) |
| ApoC-III |
EB-E3 |
9448 |
5.29 / 22.00 |
0.80 |
60.8 (51.8-69.2) |
| ApoC-III |
EB-E2 |
9751 |
4.65 / 24.2 |
0.80 |
60.8 (51.8-69.2) |
| ApoC-III |
EB-E2 |
9777.5 |
3.20 / 14.7 |
0.79 |
63.1 (54.2-71.4) |
| ApoC-III |
EB-E3 |
9453 |
7.30 / 33.20 |
0.78 |
50 (41.1-58.9) |
|
ApoC-I |
MEP-M1 |
6647 |
37.53 / 121.14 |
0.78 |
57.7 (48.7-66.3) |
| ApoC-I - truncated |
MEP-M1 |
6448 |
68.91 / 184.53 |
0.76 |
53.1 (44.1-61.9) |
| ApoC-I - truncated |
MEP-M1 |
6489 |
24.49 / 52.75 |
0.76 |
53.1 (44.1-61.9) |
|
SAA4 |
MEP-M1 |
12886 |
1.35 / 2.42 |
0.76 |
58.5 (49.5-67.0) |
| SAA4 |
MEP-M1 |
12863 |
1.53 / 2.72 |
0.74 |
59.2 (50.3-67.8) |
|
TTR |
EB-E3 |
13900 |
7.80 / 23.16 |
0.77 |
59.2 (50.3-67.8) |
| TTR |
EB-E3 |
13925 |
5.36 / 14.27 |
0.75 |
57.7 (48.7-66.3) |
| Hb beta |
FT |
8037 |
2.61 / 4.64 |
0.75 |
65.4 (56.5-73.5) |
| Albumin |
FT |
54622 |
0.73 / 0.30 |
0.76 |
61.5 (52.6-69.9) |
| Albumin |
FT |
54426 |
1.72 / 0.25 |
0.75 |
60.8 (51.8-69.2) |
| Albumin ion | MEP-M1 | 44754 | 1.06 / 0.50 | 0.76 | 57.7 (48.7-66.3) |
PCI = protein C inhibitor, ApoC-III = apolipoprotein C-III, ApoC-I = apolipoprotein C-I, SAA4 = serum amyloid A4, and TTR = transthyretin, EB = Equalizer Beads, differentially eluted yield fractions E2, and E3, MEP = Mercapto ethyl pyridine beads, differentially eluted yield fractions M1.