Table 2.
Dose (mg/kg/day) | 0 | 500 | 1000 | 2000 |
---|---|---|---|---|
Males |
|
|
|
|
Brain |
0.54 ± 0.04 a |
0.58 ± 0.05 |
0.54 ± 0.03 |
0.59 ± 0.01 |
Pituitary gland |
0.003 ± 0.0003 |
0.003 ± 0.0006 |
0.003 ± 0.0003 |
0.002 ± 0.0005 |
Liver |
3.25 ± 0.12 |
3.15 ± 0.21 |
3.06 ± 0.15 |
3.05 ± 0.15 |
Spleen |
0.19 ± 0.01 |
0.19 ± 0.03 |
0.20 ± 0.03 |
0.18 ± 0.03 |
Heart |
0.33 ± 0.02 |
0.34 ± 0.02 |
0.34 ± 0.02 |
0.34 ± 0.02 |
Thymus |
0.14 ± 0.03 |
0.16 ± 0.05 |
0.15 ± 0.03 |
0.11 ± 0.01 |
Salivary glands |
0.17 ± 0.01 |
0.17 ± 0.02 |
0.17 ± 0.01 |
0.19 ± 0.02 |
Seminal vesicle |
0.36 ± 0.08 |
0.41 ± 0.11 |
0.33 ± 0.06 |
0.38 ± 0.04 |
Prostate |
0.13 ± 0.02 |
0.13 ± 0.01 |
0.13 ± 0.02 |
0.12 ± 0.02 |
Kidneys |
0.85 ± 0.06 |
0.82 ± 0.03 |
0.83 ± 0.05 |
0.83 ± 0.05 |
Adrenal glands |
0.017 ± 0.002 |
0.015 ± 0.002 |
0.016 ± 0.002 |
0.017 ± 0.003 |
Testes |
0.89 ± 0.04 |
0.88 ± 0.13 |
0.88 ± 0.14 |
0.87 ± 0.05 |
Epididymides |
0.27 ± 0.03 |
0.27 ± 0.05 |
0.27 ± 0.02 |
0.26 ± 0.02 |
lung |
0.41 ± 0.03 |
0.40 ± 0.04 |
0.39 ± 0.02 |
0.38 ± 0.03 |
Thyroid/Parathyroid |
0.006 ± 0.001 |
0.005 ± 0.001 |
0.006 ± 0.001 |
0.005 ± 0.001 |
Females |
|
|
|
|
Brain |
0.90 ± 0.05 |
0.85 ± 0.10 |
0.87 ± 0.03 |
0.87 ± 0.02 |
Pituitary gland |
0.006 ± 0.0009 |
0.005 ± 0.0005 |
0.006 ± 0.0010 |
0.005 ± 0.0009 |
Liver |
3.25 ± 0.16 |
3.23 ± 0.13 |
3.25 ± 0.26 |
3.36 ± 0.10 |
Spleen |
0.22 ± 0.04 |
0.21 ± 0.02 |
0.23 ± 0.03 |
0.24 ± 0.02 |
Heart |
0.36 ± 0.02 |
0.35 ± 0.01 |
0.37 ± 0.02 |
0.37 ± 0.02 |
Thymus |
0.19 ± 0.02 |
0.18 ± 0.03 |
0.21 ± 0.04 |
0.21 ± 0.04 |
Salivary glands |
0.19 ± 0.02 |
0.19 ± 0.01 |
0.19 ± 0.01 |
0.21 ± 0.02 |
Kidneys |
0.85 ± 0.04 |
0.85 ± 0.02 |
0.85 ± 0.08 |
0.94 ± 0.07 |
Adrenal glands |
0.034 ± 0.004 |
0.029 ± 0.001 |
0.032 ± 0.005 |
0.034 ± 0.004 |
Ovaries |
0.042 ± 0.004 |
0.040 ± 0.005 |
0.041 ± 0.009 |
0.040 ± 0.005 |
Lung |
0.53 ± 0.02 |
0.51 ± 0.03 |
0.51 ± 0.05 |
0.50 ± 0.04 |
Thyroid/parathyroid |
0.007 ± 0.002 |
0.006 ± 0.001 |
0.007 ± 0.001 |
0.008 ± 0.001 |
Uterus/cervix | 0.23 ± 0.03 | 0.26 ± 0.12 | 0.23 ± 0.07 | 0.32 ± 0.11 |
a Values are presented as mean ± SD.