Table 3.
Hematological values of animals treated with SST for 4 weeks
| Dose (mg/kg/day) | 0 | 500 | 1000 | 2000 |
|---|---|---|---|---|
| Male rat |
|
|
|
|
| WBC (103/μL) |
11.05 ± 2.35a |
12.76 ± 1.78 |
12.68 ± 3.36 |
9.14 ± 2.40 |
| Reticulocyte (%) |
2.7 ± 0.42 |
2.7 ± 0.20 |
3.0 ± 0.73 |
2.3 ± 0.23 |
| Neutrophils (%) |
9.18 ± 2.34 |
11.28 ± 3.40 |
10.32 ± 2.35 |
14.60 ± 2.78* |
| Lymphocytes (%) |
86.5 ± 3.26 |
81.9 ± 3.25 |
84.6 ± 2.67 |
80.1 ± 3.62* |
| Eosinophils (%) |
0.8 ± 0.40 |
0.6 ± 0.09 |
0.6 ± 0.22 |
0.5 ± 0.12 |
| Monocytes (%) |
2.0 ± 0.59 |
2.7 ± 0.66 |
2.6 ± 0.63 |
2.6 ± 0.56 |
| Basophils (%) |
0.8 ± 0.20 |
1.1 ± 0.22 |
1.0 ± 0.21 |
1.3 ± 0.35 |
| Large unstained cells (%) |
0.7 ± 0.24 |
2.4 ± 2.97 |
0.9 ± 0.16 |
1.0 ± 0.34 |
| RBC (106/μL) |
8.04 ± 0.16 |
8.33 ± 0.43 |
8.15 ± 0.38 |
8.22 ± 0.55 |
| Hemoglobin (g/dl) |
15.8 ± 0.51 |
16.2 ± 0.58 |
16.1 ± 0.52 |
15.8 ± 0.49 |
| Hematocrit (%) |
47.7 ± 2.12 |
48.3 ± 1.98 |
48.1 ± 1.75 |
48.0 ± 1.76 |
| MCV (fL) |
59.2 ± 1.64 |
58.1 ± 1.68 |
59.0 ± 1.34 |
58.5 ± 1.79 |
| MCH (pg) |
19.6 ± 0.32 |
19.4 ± 0.61 |
19.8 ± 0.38 |
19.3 ± 0.75 |
| MCHC (g/dl) |
33.1 ± 0.37 |
33.5 ± 0.73 |
33.5 ± 0.44 |
32.9 ± 0.31 |
| Platelet (103/μL) |
1305 ± 225 |
1164 ± 40 |
1198 ± 67 |
1178 ± 66 |
| PT (sec) |
17.5 ± 0.86 |
17.2 ± 0.45 |
16.5 ± 0.87 |
16.7 ± 0.62 |
| APTT (sec) |
16.3 ± 0.80 |
16.7 ± 0.80 |
15.4 ± 1.11 |
16.3 ± 0.49 |
| Female rat |
|
|
|
|
| WBC (103/μL) |
8.07 ± 1.25 |
8.17 ± 2.38 |
8.27 ± 1.09 |
6.75 ± 0.56 |
| Reticulocyte (%) |
2.2 ± 0.38 |
2.7 ± 0.39 |
2.4 ± 0.58 |
2.5 ± 0.55 |
| Neutrophils (%) |
13.12 ± 6.54 |
15.92 ± 7.16 |
15.58 ± 5.63 |
13.20 ± 3.05 |
| Lymphocytes (%) |
81.6 ± 6.97 |
78.6 ± 7.19 |
79.2 ± 5.09 |
82.7 ± 2.81 |
| Eosinophils (%) |
1.0 ± 0.15 |
1.3 ± 0.38 |
1.1 ± 0.15 |
0.8 ± 0.17 |
| Monocytes (%) |
2.2 ± 0.86 |
2.6 ± 0.40 |
2.4 ± 0.61 |
1.7 ± 0.35 |
| Basophils (%) |
0.9 ± 0.21 |
0.8 ± 0.25 |
0.7 ± 0.13 |
0.9 ± 0.13 |
| Large unstained cells (%) |
1.2 ± 0.42 |
0.9 ± 0.23 |
1.0 ± 0.08 |
0.8 ± 0.26 |
| RBC (106/μL) |
8.24 ± 0.33 |
8.28 ± 0.16 |
8.18 ± 0.20 |
8.14 ± 0.13 |
| Hemoglobin (g/dl) |
15.9 ± 0.55 |
15.7 ± 0.44 |
16.0 ± 0.13 |
15.7 ± 0.19 |
| Hematocrit (%) |
46.4 ± 1.62 |
46.4 ± 1.06 |
47.0 ± 0.43 |
46.2 ± 0.73 |
| MCV (fL) |
56.4 ± 0.88 |
56.0 ± 1.67 |
57.5 ± 1.25 |
56.8 ± 0.49 |
| MCH (pg) |
19.3 ± 0.43 |
19.0 ± 0.54 |
19.6 ± 0.50 |
19.4 ± 0.35 |
| MCHC (g/dl) |
34.3 ± 0.28 |
33.9 ± 0.38 |
34.1 ± 0.40 |
34.1 ± 0.49 |
| Platelet (103/μL) |
1242 ± 76 |
1595 ± 430 |
1161 ± 100 |
1132 ± 32 |
| PT (sec) |
17.6 ± 0.43 |
18.1 ± 0.26 |
17.6 ± 0.59 |
18.3 ± 0.73 |
| APTT (sec) | 13.9 ± 0.39 | 15.4 ± 0.86 | 14.3 ± 1.10 | 14.8 ± 0.75 |
APTT, activated partial thromboplastin time; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; PT, prothrombin time.
a Values are presented as mean ± SD.
* Indicate a significant difference at P < 0.05 level, when compared with the vehicle control group.