Table 3.
Frequency of LOH mutations within microdissected targets by histological classifications
| Loci | Tumor suppressor genes |
The number (percent) of microdissected targets with LOH mutations at each loci in each histological classification |
|||||
|---|---|---|---|---|---|---|---|
|
Normal squamous |
Columnar |
Intestinal metaplasia |
Indefinite for dysplasia |
Low grade dysplasia |
High grade dysplasia |
||
| N = 82 | N = 77 | N =216 | N = 138 | N = 39 | N = 16 | ||
| 1p |
CMM1, LMYC |
1 (1%) |
0 |
13 (6%) |
20 (14%) |
11 (28%) |
5 (31%) |
| 3p |
VHL, OGG1 |
1 (1%) |
4 (5%) |
29 (13%) |
24 (17%) |
20 (51%) |
8 (50%) |
| 5q |
MCC, APC |
2 (2%) |
8 (10%) |
43 (20%) |
25 (18%) |
11 (28%) |
13 (81%) |
| 9p |
CDKN2A |
4 (5%) |
4 (5%) |
56 (26%) |
45 (33%) |
20 (51%) |
7 (44%) |
| 10q |
PTEN, MXI1 |
0 |
11 (14%) |
54 (25%) |
40 (29%) |
12 (31%) |
2 (13%) |
| 17p |
TP53 |
1 (1%) |
4 (5%) |
35 (16%) |
49 (36%) |
27 (69%) |
14 (88%) |
| 17q |
NME1 |
1 (1%) |
7 (9%) |
21 (10%) |
33 (24%) |
17 (44%) |
9 (56%) |
| 18q |
DCC |
1 (1%) |
7 (9%) |
41 (19%) |
14 (10%) |
12 (31%) |
4 (25%) |
| 21q |
TFF1, PSEN2 |
0 |
3 (4%) |
20 (9%) |
18 (13%) |
7 (18%) |
0 |
| 22q | NF2 | 0 | 0 | 11 (5%) | 3 (2%) | 0 | 2 (13%) |
Bold numbers indicate that at least 25% of microdissected targets tested with each histological classification had the indicated LOH mutations.