Table 2. SNP allele frequencies.
SNP | Gene | HD (n = 50) | CD (n = 58) | p-value |
rs1800795 | IL6 | 0.35 | 0.32 | 0.6410 |
rs1800797 | IL6 | 0.35 | 0.32 | 0.6421 |
rs1800796 | IL6 | 0.07 | 0.06 | 0.7660 |
rs4537545 | IL6R | 0.33 | 0.49 | 0.0175 |
rs2228145 | IL6R | 0.30 | 0.42 | 0.0679 |
rs10940495 | gp130 | 0.32 | 0.21 | 0.0658 |
rs715180 | gp130 | 0.09 | 0.09 | 1.0 |
Minor allele frequencies for each of the SNPs tested are depicted for HD and CD patients. IL6 SNPs rs1800795 and rs1800797 are in LD as are the two IL6R SNPs. There is a significant difference between the minor allele frequencies of the IL6R SNP rs4537545 for HD and CD patients (p = 0.0175).