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. 2013 Jan 23;8(1):e54344. doi: 10.1371/journal.pone.0054344

Figure 3. H. pylori induces inflammation in an in vivo C57BL/6 murine model.

Figure 3

(A) C57BL/6 mice were challenged with Brucella broth, as an uninfected (UI) negative control, with the mouse-adapted wild-type cag+ H. pylori strain PMSS1, or a PMSS1 cagE− isogenic mutant for 4 or 8 weeks. (B and C) A single pathologist, blinded to treatment groups, assessed and scored inflammation at 4 weeks (B) and 8 weeks (C). Acute and chronic inflammation in both the antrum and corpus was scored on a scale of 0–3, leading to a possible maximum score of 12. Each data point represents an individual animal and mean values are shown. Circles designate uninfected mice, squares represent H. pylori PMSS1-infected mice, and triangles represent H. pylori PMSS1 cagE−-infected mice. Mann-Whitney and ANOVA tests were used to determine statistical significance between groups.