Photopic illuminance to achieve 50% melatonin suppression. Several practical light sources with the required photopic illuminance (lux, or lm/m2) levels at the eye, having a fixed pupil diameter of 2.3 mm, for 50% nocturnal melatonin suppression after one hour exposure (adapted from [66]). Although the absolute numbers will vary depending on pupil area, duration of exposure, exact spectral power distribution of the light source, distance from the source, the numbers in Table 2 can be used to determine the relative effectiveness of these different light sources as it may impact acute melatonin suppression, one marker of the biological clock. Whether or not these values are the same for estimating phase shifting of the timing of the biological clock by these light sources is still not established.