Figure 1. Conditioned Place-Preference of Group 1 Mice.
Mean ± SEM of CPP scores. Group 1 mice were of an early backcrossing generation (F2) and have a mixed genetic background consisting of a roughly 1:1 ratio of the 129 and C57 strains. CPP scores are defined as the time spent in the drug-designated environment minus the time spent in the saline-designated environment. Control mice receive saline in both environments. (a) Wild-type mice (cocaine: n = 8, saline: n = 10) show a robust CPP induced by 20 mg/kg cocaine. (b) DAT-CI mice (cocaine: n = 14, saline: n = 8) showed significant CPA induced by 20 mg/kg cocaine. All statistics are two-way ANOVA comparisons of the time bias (CPP score) observed post-conditioning (open bars) relative to saline-conditioned control mice within the figure (*, p < 0.05; **, p < 0.01).