Table 3. Clustered genes from the Cadherin/Wnt and Heterotrimeric G-Protein Signaling Pathways.

The cadherin and protocadherin genes appearing in Clusters i-v are identified. Genes in the heterotrimeric G-protein signaling pathway (Gα_i and Gα_s) that fell into Clusters i-v are grouped by function; GPCRs for dopamine, GABA, glutamate and acetylcholine are discussed separately and GPCRs without known ligands are not listed. Intracellular signaling proteins are grouped by function.

		(i) Sustained Increase, Coc & W/D	(ii) Increase, W/D only	(iii) Transient Increase, Coc only	(iv) Transient Decrease, Coc only	(v) Sustained Decrease, Coc & W/D
Cadherin / Wnt Signaling
Cadherins		Cdh4, Cdh5, Cdh6, Cdh8, Cdh11	Cdh7, Cdh19, Cdh22	Cdh24	Cdh13
Protocadherins		Pcdh1, Pcdh10, Pcdh18, Pcdhb13, Pcdhb14, Pcdhb16	Pcdhb2, Pcdhb6, Pcdhb7, Pcdhb8, Pcdhb9	Pcdh20, Pcdhb5, Pcdhb10, Pcdhb11, Pcdhb19, Pcdhb20		Pcdha4, Pcdhb12, Pcdhga1, Pcdhga2, Pcdhga3, Pcdhga4, Pcdhga5, Pcdhga6, Pcdhga7, Pcdhga8, Pcdhga9, Pcdhga10, Pcdhga11, Pcdhga12, Pcdhgb1, Pcdhgb2, Pcdhgb4, Pcdhgb5, Pcdhgb6, Pcdhgb7, Pcdhgb8, Pcdhgc3, Pcdhgc4, Pcdhgc5
Heterotrimeric G-Protein Signaling (Gαi & Gαs)
Type of GPCR:
Neuropeptide binding		Fzd5, Fzd8, Hcrtr2, Npffr1, Oprk1, Oprm1, Prlhr, Tacr1	Fzd6, Fzd7, Mc3r, Oprd1, Pth1r, Smo, Trhr2	Hcrtr1, Npbwr1, Npy2r, Oxtr, Sstr3, Tacr3	Fzd9, Glpr, Nmbr, Npy5r	Mc4r, Mchr1, Mtnr1a, Sstr2
Lipid binding			S1pr3		S1pr4	Lpar1
Cadherin type		Celsr2, Celsr3	Celsr1
Intracellular signaling proteins:
GPCR kinases					Grk6	Grk1
Arrestins		Arrb1				Arrb2
Gβ subunits			Gnb4			Gnb1, Gnb1l, Gnb2, Gnb2l1, Gnb5
Gγ subunits			Gng7	Gng2		Gng3, Gng8, Gng10, Gng11, Gng13
RGSs		Rgs6	Rgs8, Rgs11	Rgs17	Rgs9, Rgs19	Rgs2, Rgs4, Rgs10, Rgs16, Rgs20
Adenylate cycases		Adcy1, Adcy4, Adcy6, Adcy9	Adcy2, Adcy5	Adcy8
Phosphorylase b kinases		Phka2				Phkg1, Phkg2
CREBs		Creb3l2, Crebbp				Creb3

Abbreviations: Coc, Cocaine; W/D, Withdrawal.