Fig. 1.

Workflow of the validation phase. After performing our routine day-3 FISH program, a second cell was biopsied on day 4 in 38 embryos diagnosed as chromosomally abnormal. Single-cell arrayCGH diagnosis was performed in those samples. Day-3 FISH and day-4 arrayCGH diagnoses were compared, and, in cases of discordant results, the whole day-5 embryo was fixed to be re-analysed by FISH using probes directed to the discordant chromosomes