Table 2.

Neutrophil components involved in NETosis.

Component	Function	Reference(s)
Neutrophil elastase (NE)	Chromatin decondensation	Papayannopoulos et al., 2010
Myeloperoxidase (MPO) HOCl	Chromatin decondensation; hypochlorite generation	Papayannopoulos et al., 2010; Metzler et al., 2011; Akong-Moore et al., 2012
Peptidylarginine deiminase type IV (PAD4)	Chromatin decondensation; histone modification	Li et al., 2010; Leshner et al., 2012
Autophagy	NETosis pathway	Remijsen et al., 2011
NADPH oxidase	NETosis pathway	Fuchs et al., 2007
H2O2	Substrate for MPO	Akong-Moore et al., 2012
Singlet oxygen	Essential NETosis inducer	Nishinaka et al., 2011
Raf-MEK-ERK	NETosis pathway	Hakkim et al., 2011
ERK, p38 MAPK	NETosis pathway	Keshari et al., 2012