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Evaluation of oral metronomic topotecan (topo). Twelve mice were orthotopically injected with HT29 human colon cancer cell and treated with control vehicle, topotecan or topotecan plus pazopanib (pazo) (n=4). Mice were sacrificed after 10 weeks. Primary tumour weights (A) and metastatic spread (B) were significantly reduced by topotecan mono- or combination therapy. Green arrows indicate hepatic metastases
