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Postmortem necropsy and single-organ bioluminescence analysis of metastatic spread. Topotecan significantly reduced metastatic spread (A), most pronounced in the liver (B). Microscopic quantification of the number of hepatic metastases per section and the average diameter of metastases are shown in panels C and D. pazo, pazopanib; topo, topotecan; UFT, uracil/tegafur.
