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. 2012 Dec 4;108(1):139–148. doi: 10.1038/bjc.2012.480

Table 3. (A) Associations between clinical variables and androgen receptor phosphorylation sites. (B) Associations between clinical variables and candidate kinases.

  Clinical variables
Proteins Age (<70 vs ⩾70 years) Gleason (<7 vs =7 vs >7) Diagnosis PSA (<10 vs 10–20 vs >20 ng ml−1 Recurrence PSA (<10 vs 10–20 vs >20 ng ml−1) Lymphovascular invasion (presence vs absence) Presence of metastases (presence vs absence) Ki67 (⩽median vs >median)
A
AR
 Cytoplasm 0.909 0.841 0.979 0.496 0.028 0.061 0.230
 Nucleus 0.284 0.450 0.301 0.380 0.006 0.107 0.154
 Total 0.422 0.464 0.493 0.800 0.002 0.027 0.627
               
pAR S81
 Cytoplasm 0.035 0.811 0.269 0.566 0.175 0.660 0.498
 Nucleus 0.651 0.401 0.462 0.601 0.666 0.229 0.039
 Total 0.220 0.425 0.389 0.632 0.290 0.195 0.041
               
pAR S94
 Cytoplasm 0.447 0.714 0.437 0.820 0.234 0.165 0.040
 Nucleus 0.651 0.069 0.726 0.386 0.234 0.892 0.361
 Total 0.754 0.417 0.964 0.496 0.864 0.554 0.191
               
pAR S308
 Cytoplasm 0.169 0.567 0.441 0.848 0.386 0.656 0.662
 Nucleus 0.854 0.324 0.049 0.413 0.836 0.601 0.284
 Total 0.515 0.651 0.109 0.375 0.769 0.906 0.531
               
pAR S515
 Cytoplasm 0.221 0.109 0.181 0.273 0.018 0.040 0.233
 Nucleus 0.042 0.336 0.052 0.116 0.673 0.948 0.156
 Total 0.048 0.120 0.287 0.120 0.463 0.528 0.229
               
pAR S650
 Cytoplasm 0.046 0.446 0.976 0.761 0.773 0.750 0.260
 Nucleus 0.018 0.531 0.169 0.935 0.279 0.216 0.756
 Total 0.020 0.465 0.216 0.827 0.516 0.447 0.504
               
B
Cdk1
 Cytoplasm 0.320 0.259 0.741 0.129 0.232 0.690 0.436
 Nucleus 0.665 0.898 0.255 0.464 0.563 0.353 0.838
 Total 0.187 0.831 0.277 0.130 0.583 0.432 0.879
               
pCdk1 161
 Cytoplasm 0.165 0.929 0.091 0.298 0.640 0.192 0.494
 Nucleus 0.084 0.255 0.164 0.047 0.389 0.259 0.630
 Total 0.044 0.263 0.108 0.017 0.621 0.204 0.918
               
pERK1/2
 Cytoplasm 0.293 0.175 0.854 0.639 0.471 0.180 0.530
 Nucleus 0.908 0.329 0.990 0.152 0.147 0.674 0.033
 Total 0.315 0.555 0.936 0.569 0.160 0.428 0.280

Abbreviations: AR=androgen receptor; PSA=prostate-specific antigen.

Cytoplasmic, nuclear and total (cytoplasmic+nuclear) expression of androgen receptor and phosphorylated androgen receptor (A) and candidate kinases (Cdk1, pCdk1161 and pERK1/2) (B) were examined for significant relationships with clinical variables as shown. Protein expression scores were used and clinical variables were divided into groups. When the clinical variable consisted of two independent groups the Mann–Whitney U-test was performed, and >2 independent groups the Kruskal–Wallis test was used. Significant associations are highlighted in bold.