Table 1. Multivariate cohort analysis of one-carbon metabolism dietary factors and endometrial cancer incidence.
| Q1 | Q2 | Q3 | Q4 | Q5 | P -trend | |
|---|---|---|---|---|---|---|
| Total folate (μg day−1)a | 275.8 | 402.0 | 509.7 | 623.8 | 794.0 | |
| Events | 123 | 174 | 163 | 172 | 156 | |
| HR (95% CI)b | Ref | 1.17 (0.93, 1.48) | 1.11 (0.87, 1.41) | 1.19 (0.94, 1.51) | 1.10 (0.87, 1.41) | 0.51 |
| Folate from food only (μg day−1)a | 214.3 | 282.7 | 336.5 | 396.4 | 493.9 | |
| Events | 127 | 146 | 165 | 168 | 182 | |
| HR (95% CI)b | Ref | 0.94 (0.74, 1.19) | 1.01 (0.80, 1.28) | 1.03 (0.81, 1.30) | 1.12 (0.88, 1.41) | 0.21 |
| Total vitamin B2 (mg day−1)a | 1.6 | 2.3 | 3.0 | 4.5 | 13.5 | |
| Events | 139 | 163 | 188 | 151 | 147 | |
| HR (95% CI)b | Ref | 1.01 (0.80, 1.27) | 1.16 (0.93, 1.45) | 0.99 (0.78, 1.25) | 0.97 (0.77, 1.23) | 0.75 |
| Vitamin B2 from food only (mg day−1)a | 1.2 | 1.5 | 1.8 | 2.1 | 2.6 | |
| Events | 118 | 166 | 142 | 203 | 159 | |
| HR (95% CI)b | Ref | 1.20 (0.94, 1.52) | 1.02 (0.79, 1.30) | 1.37 (1.09, 1.72) | 1.06 (0.83, 1.35) | 0.38 |
| Total vitamin B6 (mg day−1)a | 1.7 | 2.5 | 3.5 | 5.6 | 27.0 | |
| Events | 135 | 162 | 187 | 144 | 160 | |
| HR (95% CI)b | Ref | 1.01 (0.80, 1.27) | 1.18 (0.94, 1.48) | 0.95 (0.75, 1.21) | 1.03 (0.81, 1.29) | 0.94 |
| Vitamin B6 from food only (mg day−1)a | 1.3 | 1.6 | 1.9 | 2.2 | 2.7 | |
| Events | 128 | 148 | 147 | 175 | 190 | |
| HR (95% CI)b | Ref | 0.97 (0.76, 1.23) | 0.91 (0.71, 1.15) | 1.07 (0.84, 1.35) | 1.12 (0.89, 1.41) | 0.18 |
| Total vitamin B12 (μg day−1)a | 5.3 | 8.7 | 12.0 | 16.9 | 44.1 | |
| Events | 162 | 138 | 162 | 161 | 165 | |
| HR (95% CI)b | Ref | 0.81 (0.64, 1.02) | 0.92 (0.74, 1.15) | 0.91 (0.73, 1.14) | 0.91 (0.73, 1.13) | 0.77 |
| Vitamin B12 from food only (μg day−1)a | 3.5 | 5.0 | 6.3 | 8.0 | 10.8 | |
| Events | 143 | 157 | 146 | 170 | 172 | |
| HR (95% CI)b | Ref | 1.01 (0.80, 1.26) | 0.90 (0.71, 1.13) | 1.00 (0.80, 1.26) | 1.03 (0.82, 1.29) | 0.78 |
| Total choline (mg day−1)a | 227.3 | 281.5 | 323.6 | 370.6 | 444.8 | |
| Events | 136 | 154 | 165 | 177 | 156 | |
| HR (95% CI)b | Ref | 1.09 (0.86, 1.37) | 1.12 (0.89, 1.41) | 1.17 (0.94, 1.47) | 1.02 (0.81, 1.29) | 0.66 |
| Total methionine (g day−1)a | 1.2 | 1.5 | 1.7 | 2.0 | 2.4 | |
| Events | 144 | 151 | 170 | 151 | 172 | |
| HR (95% CI)b | Ref | 0.96 (0.76, 1.21) | 1.07 (0.85, 1.34) | 0.91 (0.72, 1.15) | 0.98 (0.78, 1.22) | 0.71 |
| Total alcohol (g day−1)a | 0.0 | 0.4 | 1.9 | 5.7 | 16.2 | |
| Events | 239 | 123 | 145 | 134 | 147 | |
| HR (95% CI)b | Ref | 0.74 (0.59, 0.92) | 0.79 (0.64, 0.98) | 0.80 (0.64, 0.99) | 0.94 (0.76, 1.18) | 0.49 |
Abbreviations: BMI=body mass index; CI=confidence interval; HR=hazard ratio.
a
Median level of each quintile. Dietary reference intake levels for women 50–70 years old: folate: 400 μg day−1, vitamin B2: 1.1 mg day−1, vitamin B6: 1.5 mg day−1, vitamin B12: 2.4 μg day−1, choline: 425 mg day−1.
b
Adjusted for calendar year (continuous), age (continuous, months), smoking (0, 0.1–20, 20.1–40, >40 pack-years), BMI (continuous, kg m−2), race (White, Black, others), age at menarche (7–11, 12, 13, 14–18 years), oral contraceptive use (no use, <1, 1–3, 3–6, >6 years), menopausal status (premenopausal, postmenopausal), postmenopausal hormone use (no use, oral conjugated oestrogen, oral oestrogen and progesterone, others), and parity (0, 1, 2, 3, >3).