Table 2. Multivariate analysis of one-carbon metabolism dietary factors and endometrial cancer incidence by MTHFR genotypesa.
|
MTHFR
677 (OR (95% CI))b |
||||
|---|---|---|---|---|
| CC ( N =484) | CT ( N =506) | TT ( N =129) | P -interaction | |
| Folate | 0.79 (0.52, 1.20) | 1.32 (0.89, 1.95) | 0.63 (0.25, 1.60) | 0.88 |
| Choline | 1.52 (1.02, 2.27) | 1.31 (0.88, 1.95) | 1.37 (0.58, 3.27) | 0.99 |
| Methionine | 1.02 (0.68, 1.53) | 0.92 (0.62, 1.36) | 1.20 (0.52, 2.78) | 0.60 |
| Vitamin B2 | 1.05 (0.70, 1.59) | 0.98 (0.67, 1.44) | 0.50 (0.19, 1.29) | 0.40 |
| Vitamin B6 | 1.02 (0.68, 1.55) | 1.30 (0.88, 1.92) | 0.30 (0.11, 0.83) | 0.37 |
| Vitamin B12 | 1.16 (0.77, 1.74) | 1.02 (0.69, 1.52) | 0.52 (0.19, 1.41) | 0.28 |
| Alcohol | 1.48 (0.97, 2.28) | 0.79 (0.53, 1.19) | 0.65 (0.26, 1.64) | 0.07 |
|
MTHFR
1298 (OR (95% CI))b |
||||
|---|---|---|---|---|
| AA ( N =498) | AC ( N =506) | CC ( N =121) | P -interaction | |
| Folate | 1.09 (0.73, 1.61) | 0.89 (0.60, 1.33) | 0.45 (0.13, 1.57) | 0.19 |
| Choline | 1.44 (0.98, 2.13) | 1.47 (0.99, 2.19) | 0.80 (0.27, 2.39) | 0.30 |
| Methionine | 0.96 (0.65, 1.42) | 1.08 (0.73, 1.61) | 0.66 (0.21, 2.06) | 0.84 |
| Vitamin B2 | 0.91 (0.61, 1.34) | 1.03 (0.70, 1.53) | 0.36 (0.11, 1.20) | 0.43 |
| Vitamin B6 | 0.88 (0.59, 1.30) | 1.08 (0.72, 1.61) | 0.44 (0.14, 1.42) | 0.63 |
| Vitamin B12 | 0.92 (0.61, 1.37) | 0.92 (0.62, 1.36) | 0.96 (0.30, 3.12) | 0.68 |
| Alcohol | 0.82 (0.55, 1.23) | 1.03 (0.67, 1.56) | 1.77 (0.62, 5.07) | 0.17 |
Abbreviations: BMI=body mass index; CI=confidence interval; OR=odds ratio.
a
Dietary factors were dichotomised at the median. ORs indicate the association magnitude for above versus below median intake, stratified by genotype. The sample sizes for the genotypes include both cases and controls.
b
Adjusted for age, smoking, BMI, race, age at menarche, oral contraceptive use, menopausal status, postmenopausal hormone use and parity.