Table 3. Associations between one-carbon metabolism SNPs and endometrial cancer incidence.

				Endometrial cancer b
SNP	Gene	MAF	Reference allele a	OR (95% CI)	P -value
rs1127717 (C,T)	ALDH1L1	0.20	C	0.97 (0.79, 1.19)	0.78
rs4646750 (C,T)	ALDH1L1	0.07	C	1.07 (0.78, 1.47)	0.68
rs2886059 (A,C)	ALDH1L1	0.16	A	1.00 (0.79, 1.26)	0.99
rs2276724 (C,T)	ALDH1L1	0.15	C	0.91 (0.72, 1.14)	0.41
rs2372536 (C,G)	ATIC	0.32	C	1.04 (0.88, 1.24)	0.65
rs3733890 (A,G)	BHMT	0.30	A	1.00 (0.83, 1.19)	0.96
rs9001 (G,T)	CHDH	0.05	G	1.14 (0.78, 1.67)	0.49
rs12676 (A,C)	CHDH	0.30	A	0.87 (0.73, 1.03)	0.10
rs1021737 (G,T)	CTH	0.29	G	0.85 (0.71, 1.02)	0.08
rs2228612 (C,T)	DNMT1	0.06	C	0.95 (0.67, 1.35)	0.78
rs202676 (T,C)	FOLH1	0.22	T	1.26 (1.03, 1.54)	0.03
rs8788 (C,T)	GART	0.17	C	0.99 (0.79, 1.24)	0.93
rs8971 (C,T)	GART	0.24	C	0.90 (0.74, 1.09)	0.29
rs11545077 (C,T)	GGH	0.25	C	1.15 (0.96, 1.37)	0.13
rs11545078 (A,G)	GGH	0.10	A	0.87 (0.65, 1.15)	0.32
rs2236225 (A,G)	MTHFD1	0.45	A	1.02 (0.87, 1.21)	0.79
rs1950902 (A,G)	MTHFD2	0.18	A	0.97 (0.78, 1.19)	0.75
MTHFR 677 (C,T)	MTHFR	0.34	C	1.06 (0.89, 1.27)	0.50
MTHFR 1298 (A,C)	MTHFR	0.33	A	1.03 (0.87, 1.23)	0.71
rs1805087 (A,G)	MTR	0.19	A	1.03 (0.84, 1.26)	0.79
rs1801394 (A,G)	MTRR	0.47	A	1.10 (0.93, 1.30)	0.25
rs1532268 (C,T)	MTRR	0.37	C	0.98 (0.82, 1.16)	0.78
rs2287780 (C,T)	MTRR	0.04	C	0.73 (0.47, 1.14)	0.16
rs16879334 (C,G)	MTRR	0.04	C	0.79 (0.50, 1.24)	0.30
rs162036 (A,G)	MTRR	0.11	A	1.27 (0.97, 1.67)	0.09
rs10380 (C,T)	MTRR	0.09	C	1.19 (0.89, 1.59)	0.25
rs7946 (T,C)	PEMT	0.25	T	0.96 (0.80, 1.15)	0.68
rs1979277 (A,G)	SHMT1	0.29	A	0.87 (0.73, 1.03)	0.11
rs1051266 (C,T)	SLC19A1	0.44	C	0.97 (0.82, 1.14)	0.68

Abbreviations: CI=confidence interval; MAF=minor allele frequency; OR=odds ratio; SNP=single-nucleotide polymorphism.

^a The homozygous genotype of the reference allele was coded as 0.

^b Adjusted for the matching factors age and menopausal status.