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. Author manuscript; available in PMC: 2014 Jan 16.
Published in final edited form as: Cell Host Microbe. 2013 Jan 16;13(1):100–107. doi: 10.1016/j.chom.2012.11.012

Figure 3. USA300 polyamine-resistance is essential for persistence during the post-inflammatory wound healing response.

Figure 3

A. Viable cfu per abscess of WT USA300 and isogenic ΔspeG at 3, 7 and 12 dpi. Significance was assessed via Mann-Whitney. B. Viability of WT USA300 clones (SF8300 (SF) and LAC) and isogenic ΔspeG mutants in 12-day abscesses. Repaired ΔspeG (SF ΔspeG∷speG) is fully virulent. DFMO treatment abrogates ΔspeG attenuation. C. Increasing polyamine levels (nmol/mg tissue) detected in S. aureus abscesses throughout the infection. (*) significantly higher levels compared with day 0. ($) significantly reduced levels in tissue from DFMO treated animals (p< 0.05 Man-Whitney). D. Immunofluorescent staining of day 12 abscesses imaged at 20× magnification from mice treated with/without DFMO using indicated antibodies and counterstained with DAPI.