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. Author manuscript; available in PMC: 2014 Jan 16.
Published in final edited form as: Cell Host Microbe. 2013 Jan 16;13(1):100–107. doi: 10.1016/j.chom.2012.11.012

Figure 4. Polyamines are critical during sepsis, but levels are not sufficient to directly kill S. aureus.

Figure 4

A. Survival of eight 4–6 week female C57BL/6 mice (treated or untreated with DFMO) following i.v. inoculation with 5 × 106 cfu of USA300 S. aureus or MSSA strain Newman. DFMO treatment significantly exacerbated disease outcomes for both USA300 and Newman infections (p < 0.05, Kaplan Meier). B. Weight loss following i.v. inoculation of 8 mice with 5 × 106 cfu of WT USA300 and isogenic ΔACME or ΔspeG mutants. C. Organ tissue polyamines levels detected 7 days after infection when mice begin to resume weight gain compared with levels found in resolving S. aureus abscesses.