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Abnormal autoregulation in glaucoma and factors that may contribute. Primary vascular dysregulation, endothelial dysfunction, astrocyte activation and increased intraocular pressure induce compromised autoregulation leading to abnormal pressure-flow relationship. Periods of ischemia are then more likely to occur when ocular perfusion pressure (OPP) is reduced, when OPP fluctuates and when intraocular pressure (IOP) is increased.
