Skip to main content
. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Pharmacogenomics. 2012 Sep;13(12):1387–1404. doi: 10.2217/pgs.12.126

Figure 3. Module network analysis of a treatment-dependent protein interaction network.

Figure 3

Ingenuity pathway analysis of a treatment response-induced, IL13-dependent cluster identified key regulatory genes TGF-β1 and JUNB. Eight of the network proteins were regulated by TGF-β1, which in turn is activated or induced by THBS1, MMP14 and IL13 in a positive-feedback loop. Proteins are represented by nodes, and edges indicate all interactions other than coexpression. Nodes of dark blue indicate IL13-dependent expression (i.e., genes that are induced by treatment only in the presence of IL13).

Reproduced with permission from [108] © 2008, American Thoracic Society.