Fig 2.

Viral replication in airway epithelial cells. Depending on the receptor type, virus uptake occurs via clathrin-dependent or -independent endocytosis or via macropinocytosis. A drop in the pH leads to viral uncoating. Negative-strand (parental) RNA is replicated as well as translated into structural (capsid) and nonstructural proteins. The virion is then assembled and packaged prior to cellular export via cell lysis (6, 7). LDLR, low-density-lipoprotein receptor; ICAM-1, intercellular adhesion molecule 1.