Fig 5.

Phylogenetic tree. Shown are circle phylogram relationships for known genotypes of HRV-A, HRV-B, and HRV-C. The tree was calculated with neighbor-joining methods from aligned, full-genome RNA sequences and rooted with data for human enterovirus species A, B, and C. The outer ring (“1” or “2”) indicates anticapsid drug group types, if known. The inner ring shows members of the major (“M”) (ICAM-1) and minor (“m”) (LDLR) receptor groups. The HRV-C receptor is unknown. Since few HRV-C strains are fully sequenced, the determination of relationships among these genotypes relies on partial VP1 RNA data (bottom left). Bootstrap values (percentages of 2,000 replicates) are indicated at key nodes. (Reprinted from reference 228 with permission of Wolters Kluwer Health/Lippincott Williams & Wilkins.)