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Structures and in vitro trypanotoxic dose-response activities of CBK3974 (A), CBK3987 (B), and CBK201352 (C). Serial dilutions of compounds were incubated with T. brucei subsp. brucei for 72 h, and viability was determined with the WST-1 assay. IC50 calculations are based on averages from triplicate measurements with standard errors.
