Table 4.

Pharmacokinetic variables in all patients

Variable and populationa	Value for the indicated drugb
	MEM		TZP		CEF
	Mean (range)	P	Mean (range)	P	Mean (range)	P
Vd (liters)
Obese	40.0 (8.0–191.0)		29.6 (14.3–51.3)		24.0 (15.3–149.2)
Nonobese	27.9 (5.4–205.2)	0.103	21.3 (1.3–165.7)	0.068	21.4 (13.1–48.9)	0.488
Indexed Vd (liters/kg)
Obese	0.3 (0.1–1.6)		0.3 ((0.1–0.4)		0.3 (0.1–1.6)
Nonobese	0.5 (0.1–3.0)	0.001	0.3 (0.0–2.7)	0.003	0.4 (0.2–0.8)	0.65
CL (ml/min)
Obese	101.0 (6.4–487.6)		90.2 (31.5–271.6)		51.0 (7.4–174.3)
Nonobese	77.0 (35.0–390.0)	0.424	53.5 (13.8–547.0)	0.093	47.0 (1.3–181.0)	0.686
CL with CRRT (ml/min)
Obese	75.5 (6.4–188.9)		74.4 (44.4–271.6)		27.7 (10.5–39.7)
Nonobese	61.8 (38.5–390.0)	0.685	53.5 (13.8–115.2)	0.178	25.0 (19.7–101.3)	0.827
CL without CRRT (ml/min)
Obese	168.0 (26.7–487.6)		167.1 (31.5–256.6)		73.4 (7.4–174.3)
Nonobese	102.0 (35.0–275.0)	0.209	85.0 (21.7–547.0)	0.529	49.8 (1.3–151.0)	0.965
t1/2 (h)
Obese	3.7 (1.3–115.5)		3.2 (1.6–18.2)		3.0 (0.6–28.9)
Nonobese	4.3 (1.0–15.1)	0.841	3.8 (1.0–15.2)	0.397	9.1 (1.3–115.5)	0.157
t1/2 with CRRT (h)
Obese	5.5 (2.3–115.5)		2.5 (1.8–7.7)		2.4 (1.7–23.1)
Nonobese	4.8 (2.0–15.1)	0.617	2.9 (1.3–9.0)	0.491	15.8 (13.1–30.6)	0.513
t1/2 without CRRT (h)
Obese	1.6 (1.3–57.8)		3.0 (1.6–18.2)		5.5 (0.6–28.9)
Nonobese	1.3 (1.0–8.3)	0.448	3.5 (1.0–15.2)	0.674	5.0 (1.3–115.5)	0.251

^aVd, volume of distribution; CL, clearance; t_1/2, half-life; CRRT, continuous renal replacement therapy.

^bBoldface indicates significant P values.