Table 5.

Total daily doses necessary to reach pharmacodynamic targets for all patients

Drug	Minimum median dose (range) by cohort and/or treatment (g)a
	Total population			With CRRT			Without CRRT
	Obese	Nonobese	P value	Obese	Nonobese	P value	Obese	Nonobese	P valueb
MEM	2 (1–9)	2 (1–7)	0.433	1 (1–2)	1 (1–7)	0.272	3 (1–5)	2 (1–3)	0.011
TZP	12 (6–76)	12 (4–76)	0.422	8 (4–76)	12 (4–16)	0.921	24 (8–40)	20 (4–76)	0.674
CEF	4 (2–18)	10 (2–30)	0.419	2 (2–4)	6 (2–12)	0.127	12 (2–24)	12 (2–30)	0.757

^aCRRT, continuous renal replacement therapy.

^bBoldface indicates a significant P value.