Table 3.
Final parameter estimates and bootstrap results
| Parameter | Description (units) | Estimation results (estimate [% RSE])a | Bootstrap results (mean [95% CI]) |
|---|---|---|---|
| Fixed effects | |||
| CL = (1−CRRT) · (θ1 + CLCR · θ4 + TBI · θ7 + SEPS · θ9) + CRRT · θ3 | |||
| θ1 | CL intercept nonseptic, ≥30 days postburn patients without CRRT (liters/h) | 0.693 (28.3) | 0.622 (0.116–1.03) |
| θ3 | CL in patients with CRRT (liters/h) | 1.85 (4.3) | 1.86 (1.70–2.06) |
| θ4 | Proportionality constant between CL and CLCR/120 | 0.557 (28.9) | 0.593 (0.180–0.993) |
| θ7 | Increase of CL within 30 postburn days (liters/h) | 0.504 (36.3) | 0.580 (0.293–0.946) |
| θ9 | Decrease of CL due to sepsis (liters/h) | −0.369 (45.0) | −0.390 (−0.0649–−0.730) |
| V = θ2 + (WT/65) · θ5 + EDEM · θ6 + TBI · θ8 | |||
| θ2 | V intercept in nonedematous, ≥30 days postburn patients (liters) | NEb | |
| θ5 | Proportionality constant between V and WT (liters/kg) | 50.3 (6.8) | 50.6 (43.9–59.0) |
| θ6 | Increase of V due to edema (liters) | 13.6 (33.3) | 13.5 (5.35–22.6) |
| θ8 | Increase of V within 30 postburn days (liters) | 9.61 (43.1) | 9.44 (0.37–17.7) |
| Random effects (estimates, % CV) | |||
| ω12 | BSV of CL in the patients without CRRT | 35.7 (19.8) | 32.4 (24.8–40.4) |
| ω22 | BSV of V | 17.4 (36.5) | 15.9 (8.91–22.2) |
| ω32 | BSV of CL in the patients with CRRT | 16.1 (30.5) | 15.0 (9.84–20.6) |
| Residual error | |||
| σ12 | Residual error (proportional) | 0.111 (11.0) | 0.110 (0.0883–0.135) |
a
RSE, relative standard error.
b
NE: Not estimated.