The V656A mutant exhibits substantial drug hypersensitivity. The sensitivity of the V656A mutant (▼, blue line) was compared to those of the isogenic controls (□ and red, Δpdr5 strain; ▲ and green, WT; ◆ and violet, V656L) for relative resistance to clo (A), cyh (B), bifonazole (C), tamoxifen (D), and climbazole (E) in liquid culture as described in the experimental procedures. All concentrations are in μM units. Error bars denote standard errors. n = 3.