Table 1.
Enhancement of drug resistance in the V656L mutant is independent of substrate strength
| Compound | WT/Δpdr5 IC50 ratio | IC50 (μM) |
V656L mutant/WT IC50 ratio | ATPase IC50 (μM) | |
|---|---|---|---|---|---|
| WT | V656L mutant | ||||
| Tamoxifen | 1.7 | 13 | 18 | 1.4 | Incomplete |
| Cyprodinil | 2.0 | 140 | 140 | 1.0 | 200 |
| Cerulenin | 10 | 14 | 28 | 2.0 | No inhibition |
| Imazalil | 10 | 4.3 | 7.7 | 1.8 | Incomplete |
| Cycloheximide | 17 | 7.5 | 16 | 2.1 | No inhibition |
| Bifonazole | 19 | 3.7 | 5.7 | 1.5 | 5.3 |
| Climbazole | 40 | 14 | 28 | 2.0 | Incomplete |
| Clotrimazole | 75 | 9.7 | 9.7 | 1.0 | 2.5 |
| Tebuconazole | 80 | 6.2 | 9.5 | 1.5 | No inhibition |
| Cyproconazole | 106 | 7.5 | 15 | 2.0 | No inhibition |