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In vitro antifungal activity of FK506 against the AF293 (wild-type), F16134 (multi-azole-resistant), and EMFR-S678P (echinocandin-resistant) strains. FK506 at the concentration of 0.016 to 0.032 μg/ml is active against all three strains, inducing morphological abnormalities (dense, blunted hyphae with extensive branching) and a substantial hyphal growth defect. Light-microscopy photographs (×10 magnification) after 24 h of growth at 37°C.
