Fig 2.

(a) Superposition of the GIM-1 structures showing the Zn²⁺ ions and Zn²⁺ ligands with GIM-1 chains A (cyan), B (dark blue), and C (light blue); GIM-1-2Mol chains A (black) and B (magenta); GIM-1-Apo chains A (yellow) and B (tan); and GIM-1-Ox chains A (gray) and B (green). (b) Interactions involving Trp228 in the closed GIM-1 chain A (cyan) and open GIM-1-2Mol chain A (gray). Calculated electrostatic surfaces of superimposed closed GIM-1 (chain A) (c), open GIM-1-2Mol (chain A) (d), IMP-1 (PDB 1DD6) (e), and VIM-7 (PDB 2Y87) (f), where ceftazidime is docked in VIM-7 (22), are also shown. All figures were made with PyMol (http://www.pymol.org).