Fig 6.

Fungal tissue burdens of mice infected with C. glabrata DSY562 and DSY565 and treated with fluconazole (FLC) and commercial milbemycins (Mil: A3Ox/A4Ox mix, 2.5:7.5) or their combination. The regimens for milbemycin and FLC were 2.5 and 100 mg/kg/day, respectively. Each data point corresponds to one animal, and the origin of tissue (kidney or spleen) is shown for each diagram. Geometric means are indicated by horizontal bars, and asterisks indicate statistically significant differences (*, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001). NS, no significance (P > 0.05). CFU counts were analyzed with nonparametric Wilcoxon rank-sum tests.