Fig 9.

Cluster analysis of coregulated and ortholog genes between C. albicans and C. glabrata. Gene orthologues were obtained from data available at Candida Genome database (CGD) and were extracted from data available on Files S1 and S3 in the supplemental material. Genes were clustered with the CLUSTER 3.0 software using centroid linkage preset. The data were viewed with TreeView (version 1.1.6r2). Gene symbols contain the C. albicans with the corresponding C. glabrata ortholog and the attached gene name. Three subclusters are shown. (A) Genes upregulated in C. albicans and C. glabrata; (B) genes downregulated in C. albicans and down-/upregulated in C. glabrata; (C) genes upregulated in C. albicans and downregulated in C. glabrata. “Fold-Ca” and “Fold-Cg” indicate the fold change expression in the presence of A3Ox compared to untreated controls. Arrows indicate genes assigned by GO term analysis to oxidoreductive processes (see File S3 in the supplemental material for details). The colored scale corresponds to the fold changes in gene expression ranging from <3.5-fold to >3.5-fold.