Table 4.
FIC indexes of combination of fluconazole with milbemycins
| Isolate | Milbemycin derivativea |
|||||||
|---|---|---|---|---|---|---|---|---|
| A3Ox |
A4Ox |
A3 |
A4 |
|||||
| Index | Drug effect | Index | Drug effect | Index | Drug effect | Index | Drug effect | |
| C. glabrata | ||||||||
| DSY562 | 0.4 | Synergism | 0.8 | Additivity | 1 | Additivity | 1 | Additivity |
| DSY565 | 0.6 | Additivity | 0.4 | Synergism | 0.8 | Additivity | 0.6 | Additivity |
| DSY529 | 0.5 | Synergism | – | – | – | – | – | – |
| DSY530 | 0.6 | Additivity | – | – | – | – | – | – |
| DSY726 | 0.4 | Synergism | – | – | – | – | – | – |
| DSY727 | 0.6 | Additivity | – | – | – | – | – | – |
| C. albicans | ||||||||
| DSY294 | 0.4 | Synergism | 0.4 | Synergism | 0.3 | Synergism | 0.3 | Synergism |
| DSY296 | 0.1 | Synergism | 0.2 | Synergism | 0.6 | Additivity | 0.2 | Synergism |
| DSY2321 | 0.6 | Additivity | – | – | – | – | – | – |
| DSY2323 | 0.1 | Synergism | – | – | – | – | – | – |
| DSY741 | 0.6 | Additivity | – | – | – | – | – | – |
| DSY742 | 1.1 | Indifference | – | – | – | – | – | – |
a
Index, FIC indexes were calculated as described in Materials and Methods. Drug effect, interpretation corresponded to the following definitions: synergism, FIC index ≤ 0.5; additivity, FIC index >0.5 and ≤1; and indifference, FIC index >1 and <4. –, Not tested.