Table 4.

C. glabrata genes upregulated ≥2-fold in response to both STB5 deletion (cgstb5Δ) in 84 host and PDR1 overexpression (PDR1OE)^a

Group	C. glabrata designation	S. cerevisiae homologue	Description	Fold expression upregulation
				Δcgstb5	CgPDR1OE	Δpdr1 Δcgstb5
Small-molecule transport	CAGL0B04455g	AVT4	Export of large neutral amino acids from vacuoles	2.21	8.99	3.06
	CAGL0H06017g	FLR1	Multidrug transporter of the major facilitator superfamily	2.28	4.3	5.85
	CAGL0B04433g	FUR4	Uracil and cation symporter activity	2.51	2.74	1.37
	CAGL0M01760g	PDR5	ABC transporter involved in azole/multidrug resistance	8.75	13.07	1.89
	CAGL0B02475g	PHO84	High-affinity inorganic phosphate transporter and low-affinity manganese transporter	4.48	8.34	3.23
	CAGL0K00715g	RTA1	Involved in 7-aminocholesterol resistance	2.75	3.93	0.89
	CAGL0L13354g	THI7	Putative nicotinamide transporter	4.2	5.5	40.35
	CAGL0C03289g	YBT1	ABC transporter involved in bile acid transport	2.98	5.11	1.67
	CAGL0G00242g	YOR1	ABC transporter involved in oligomycin/multidrug efflux	7.04	2.74	0.58
Transcription	CAGL0K04257g	RME1	Zinc finger protein involved in control of meiosis	4.32	8.38	4.20
	CAGL0L05786g	YPR013c	Uncharacterized; potential zinc finger	4.39	3.35	2.61
	CAGL0M01870g	YPR013c	Uncharacterized; potential zinc finger	3.74	2.23	0.77
DNA damage response	CAGL0M02035g	REV3	DNA repair and translesion synthesis	3.85	3.38	1.63
	CAGL0M09713g	YIM1	Implicated in DNA damage response	8.24	9.89	1.81
Biosynthesis	CAGL0H09064g	FUR1	Putative uracil phosphoribosyltransferase	2.57	4.78	1.68
	CAGL0M12881g	URA1	Dihydroorotate dehydrogenase	2.52	3.04	2.43
	CAGL0L05676g	URA2	Bifunctional carbamoylphosphate synthetase	4.08	3.21	1.97
Cell wall	CAGL0I10362g	FLO5	Cell wall adhesin	17.12	15.35	1.68
	CAGL0B00616g	SPS22	Implicated in organization of the beta-glucan layer of the spore wall	3.5	10.72	1.21
Cell organization	CAGL0E01265g	NUM1	Protein required for nuclear migration	3.3	2.74	1.52
Mitochondria	CAGL0M12232g	AIM1	Involved in mitochondrial function or organization	4.15	2.76	1.13
	CAGL0I09394g	FMP21	Uncharacterized	2.78	3.76	1.70
	CAGL0D01496g	ISA2	Protein required for maturation of mitochondrial and cytosolic Fe/S proteins	2.16	4.24	1.03
	CAGL0M12947g	YIL077c (PUP1)	Mitochondrial protein of unknown function	16.17	22.93	1.89
	CAGL0J04004g	YOR228c	Uncharacterized protein of the mitochondrial outer membrane	4.48	3.1	0.94
Other metabolism	CAGL0K05775g	ACN9	Carbon utilization and regulation of gluconeogenesis	2.61	2.52	1.23
	CAGL0M07271g	GRX5	Disulfide oxidoreductase activity and response to oxidative stress	3.41	2.17	0.85
	CAGL0E01705g	MDH2	l-malate dehydrogenase	2.16	3.37	1.20
	CAGL0J00847g	SDH1	Flavoprotein subunit of succinate dehydrogenase	5.29	4.1	1.64
	CAGL0E03850g	SDH2	Iron-sulfur subunit of sucinate dehydrogenase	4.63	2.52	1.21
	CAGL0F05863g	SDH4	Membrane anchor subunit of succinate dehydrogenase	2.89	2.48	1.25
	CAGL0M14091g	No similarity	Putative quinone reductase/NADPH dehydrogenase	5.45	13.68	1.39
Uncharacterized	CAGL0L05434g	NCA3	Uncharacterized	2.46	13.28	2.14
	CAGL0M12210g	YAL044W-A	Uncharacterized	3.37	2.33	1.11

^aΔpdr1Δstb5 was added for comparison.