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. 2013 Feb;57(2):959–967. doi: 10.1128/AAC.01278-12

Table 4.

C. glabrata genes upregulated ≥2-fold in response to both STB5 deletion (cgstb5Δ) in 84 host and PDR1 overexpression (PDR1OE)a

Group C. glabrata designation S. cerevisiae homologue Description Fold expression upregulation
Δcgstb5 CgPDR1OE Δpdr1 Δcgstb5
Small-molecule transport CAGL0B04455g AVT4 Export of large neutral amino acids from vacuoles 2.21 8.99 3.06
CAGL0H06017g FLR1 Multidrug transporter of the major facilitator superfamily 2.28 4.3 5.85
CAGL0B04433g FUR4 Uracil and cation symporter activity 2.51 2.74 1.37
CAGL0M01760g PDR5 ABC transporter involved in azole/multidrug resistance 8.75 13.07 1.89
CAGL0B02475g PHO84 High-affinity inorganic phosphate transporter and low-affinity manganese transporter 4.48 8.34 3.23
CAGL0K00715g RTA1 Involved in 7-aminocholesterol resistance 2.75 3.93 0.89
CAGL0L13354g THI7 Putative nicotinamide transporter 4.2 5.5 40.35
CAGL0C03289g YBT1 ABC transporter involved in bile acid transport 2.98 5.11 1.67
CAGL0G00242g YOR1 ABC transporter involved in oligomycin/multidrug efflux 7.04 2.74 0.58
Transcription CAGL0K04257g RME1 Zinc finger protein involved in control of meiosis 4.32 8.38 4.20
CAGL0L05786g YPR013c Uncharacterized; potential zinc finger 4.39 3.35 2.61
CAGL0M01870g YPR013c Uncharacterized; potential zinc finger 3.74 2.23 0.77
DNA damage response CAGL0M02035g REV3 DNA repair and translesion synthesis 3.85 3.38 1.63
CAGL0M09713g YIM1 Implicated in DNA damage response 8.24 9.89 1.81
Biosynthesis CAGL0H09064g FUR1 Putative uracil phosphoribosyltransferase 2.57 4.78 1.68
CAGL0M12881g URA1 Dihydroorotate dehydrogenase 2.52 3.04 2.43
CAGL0L05676g URA2 Bifunctional carbamoylphosphate synthetase 4.08 3.21 1.97
Cell wall CAGL0I10362g FLO5 Cell wall adhesin 17.12 15.35 1.68
CAGL0B00616g SPS22 Implicated in organization of the beta-glucan layer of the spore wall 3.5 10.72 1.21
Cell organization CAGL0E01265g NUM1 Protein required for nuclear migration 3.3 2.74 1.52
Mitochondria CAGL0M12232g AIM1 Involved in mitochondrial function or organization 4.15 2.76 1.13
CAGL0I09394g FMP21 Uncharacterized 2.78 3.76 1.70
CAGL0D01496g ISA2 Protein required for maturation of mitochondrial and cytosolic Fe/S proteins 2.16 4.24 1.03
CAGL0M12947g YIL077c (PUP1) Mitochondrial protein of unknown function 16.17 22.93 1.89
CAGL0J04004g YOR228c Uncharacterized protein of the mitochondrial outer membrane 4.48 3.1 0.94
Other metabolism CAGL0K05775g ACN9 Carbon utilization and regulation of gluconeogenesis 2.61 2.52 1.23
CAGL0M07271g GRX5 Disulfide oxidoreductase activity and response to oxidative stress 3.41 2.17 0.85
CAGL0E01705g MDH2 l-malate dehydrogenase 2.16 3.37 1.20
CAGL0J00847g SDH1 Flavoprotein subunit of succinate dehydrogenase 5.29 4.1 1.64
CAGL0E03850g SDH2 Iron-sulfur subunit of sucinate dehydrogenase 4.63 2.52 1.21
CAGL0F05863g SDH4 Membrane anchor subunit of succinate dehydrogenase 2.89 2.48 1.25
CAGL0M14091g No similarity Putative quinone reductase/NADPH dehydrogenase 5.45 13.68 1.39
Uncharacterized CAGL0L05434g NCA3 Uncharacterized 2.46 13.28 2.14
CAGL0M12210g YAL044W-A Uncharacterized 3.37 2.33 1.11
a

Δpdr1Δstb5 was added for comparison.