Fig 1.

Effect of vancomycin on Clostridium difficile-infected mice during acute infection and posttreatment. C57BL/6 mice were inoculated with VPI 10463 at 10⁴ to 10⁵ by oral gavage on day 0. The results were data pooled from 94 mice from 3 1-week-long and 2 2-week-long experiments: 20 uninfected mice, 31 infected mice, 26 mice infected and treated with vancomycin, and 17 mice infected and treated with nitazoxanide. (A) Survival curve. P < 0.0001 for uninfected versus infected mice, P = 0.0064 for infected mice versus mice infected and treated with vancomycin, and P = NS for infected mice versus mice infected and treated with nitazoxanide by the log rank (Mantel-Cox) test. (B) Mean diarrhea scores. *, P < 0.05 to 0.001 for uninfected versus infected mice; #, P < 0.05 to 0.001 for infected mice versus mice infected and treated with vancomycin; and ##, P < 0.05 for uninfected mice versus mice infected and treated with vancomycin; statistical significance was determined by two-way ANOVA with Bonferroni's correction.