Fig 4.

Effect of duration of vancomycin treatment on disease and survival in mice with CDI. For panels A and B, mice were infected with VPI 10463 (10⁵) and treated or not with vancomycin (50 mg) given for 1, 2, 3, or 5 days. Each treatment group, including uninfected and infected controls, had 8 mice each. For panel C, infected mice were treated with vancomycin (20 mg) given for either 5 days or 10 days. Each treatment group had 6 mice. (A) Survival curve. P = 0.026 by log rank test for trend; P = 0.004 for infected versus uninfected mice and P = 0.092 for infected controls versus mice treated with vancomycin for 1 day by log rank (Mantel-Cox) test. (B) Histopathology scores of colonic and cecal tissues at time of sacrifice and/or at the end of the observation period. (C) Survival curve. P = 0.3790 by log rank test for trend.