Fig 5.
Effect of vancomycin, fidaxomicin, or metronidazole on Clostridium difficile-infected mice during acute infection and posttreatment. C57BL/6 mice were inoculated with VPI 10463 at 105 by oral gavage on day 0. Anti-C. difficile drugs (20 mg/kg/day) were given from days 1 to 5. Each group had 6 mice. (A) Survival curve. P = 0.42 by log rank test for trend. (B) Fecal TcdA and TcdB levels. OD, optical density. (C) Histopathology scores from sacrificed moribund mice (at any day) and surviving mice (at the end of the study). P = 0.36 by one-way ANOVA.