Fig 6.

Effect of preexposure to vancomycin, fidaxomicin, or metronidazole on C. difficile-infected mice. All mice were pretreated with an antibiotic cocktail from day −6 to day −1 (described in the text), then given anti-C. difficile drugs (20 mg/kg/day) or not (untreated control) from days 1 to 5, and then infected with VPI 10463 at day 10. Each treatment group had 6 mice. (A) Survival curve. P = 0.11 by log rank test for trend. (B) Fecal TcdA and TcdB levels by ELISA. (C) Fecal Bacteroides levels by PCR. (D) Histopathology scores. P = 0.03 by one-way ANOVA.