Table 1.

Cytochrome P450 isoenzyme genes and N-acetyltransferase 2 genes involved in metabolism of antimalarial drugs

Enzyme(s)	Antimalarial drugs (reference[s])
CYP2A6 and CYP2B6	Artemisinins (25, 28, 62–67)
CYP2C8	Amodiaquine (25, 28, 68–70), chloroquine (25, 64, 71, 72), and dapsone (64)
CYP2C9 and NAT2	Dapsone (25, 64), sulfamethoxazole (69, 72, 73), and sulfadoxine (74)
CYP2C19	Artemether (75), dapsone (63), and proguanil (23, 25, 62, 76, 77)
CYP2D6	Chloroquine (5, 63, 71) and halofantrine (78)
CYP3A4	Artemisinins (25, 28, 62, 64, 65, 76), chloroquine (25, 63, 70, 71), dapsone (25, 63), halofantrine (25, 76, 78), lumefantrine (28, 48, 76), mefloquine (25, 28, 79–81), primaquine (25), and quinine (25, 75, 80–84)
CYP3A5	β-Arteether (25, 64), artemether (48), chloroquine (25, 70), halofantrine (25), lumefantrine (25), mefloquine (79), and quinine (80)