Table 3.

List of deletions of S. cerevisiae genes conferring altered fitness scores to only one of the four tested peptides^a

ORF	Gene	Intensity ratiob				Biological process
		MUC7	HSN	KR20	hLF
YLR360W	VPS38	1.96	−0.18	0.30	0.45	Late endosome to vacuole transport
YOR310C	NOP58	1.34	−0.66	−0.33	0.05	Pre-rRNA processing
YIL153W	RRD1	−1.69	−0.05	−0.15	0.91	Response to stress
YIR012W	SQT1	0.29	1.38	−0.33	0.31	Ribosomal assembly
YMR231W	PEP5	0.29	1.35	0.26	0.27	Late endosome to vacuole transport
YLR376C	PSY3	0.14	−1.89	−0.33	−0.13	Recombinatorial repair
YDR495C	VPS3	−0.30	−1.92	−0.46	0.45	Protein targeting to vacuole
YOR089C	VPS21	−0.14	−2.07	0.22	0.58	Protein targeting to vacuole
YFR009W	GCN20	0.10	−0.10	1.48	0.36	Regulation of translational elongation
YIL064W	SEE1	0.49	0.39	1.34	0.32	Vesicle-mediated transport
YOR005C	DNL4	−0.14	−0.24	1.31	−1.07	Double-strand break repair
YOR270C	VPH1	−0.01	−0.42	−1.35	0.61	Vacuolar acidification
YPR187W	RPO26	0.00	0.34	−1.35	−0.16	Transcription
YJR033C	RAV1	0.82	0.11	−1.37	0.04	Vacuolar acidification
YNL248C	RPA49	−0.17	−0.32	−1.43	0.27	RNA polymerase I subunit A49
YNL262W	POL2	0.27	−0.21	−1.88	0.53	DNA synthesis involved in DNA repair
YKL143W	LTV1	0.14	−0.28	−0.92	1.66	Response to oxidative and osmotic stress
YOR233W	KIN4	0.36	0.00	0.07	1.61	Mitotic spindle orientation checkpoint
YPR133W-A	TOM5	0.32	−0.24	0.14	1.38	Protein targeting to mitochondrion
YJL130C	URA2	0.33	−0.81	0.14	1.31	Pyrimidine base biosynthetic process
YBL097W	BRN1	0.93	0.37	0.09	−1.35	Mitotic chromosome condensation
YGR185C	TYS1	2.11	0.15	0.96	−1.37	Tyrosyl-tRNA aminoacylation
YDR310C	SUM1	−0.19	0.20	0.53	−1.41	Negative regulation of transcription,
YPR094W	RDS3	0.03	−0.03	−0.16	−1.44	spliceosome assembly
YCR036W	RBK1	0.46	0.40	0.58	−1.76	D-ribose metabolic process
YDL235C	YPD1	0.68	−0.15	−0.11	−2.00	osmosensory signaling pathway
YER125W	RPS5	0.11	0.23	0.18	−2.27	E3 ubiquitin ligase
YIL051C	MMF1	0.24	0.63	0.70	−2.42	mitochondrial translation

^aThe list is limited to deletions exhibiting the following fitness scores: for sensitive strains, at least 1.3 for one peptide and less than 0.5 for all other three peptides; for resistant strains, at least −1.3 for one peptide and more than −0.5 for all other three peptides. Fitness scores specific to one peptide treatment are in bold.

^bLog₂ hybridization intensity ratio between untreated and treated samples.