Table 1.
Patterns of rifaximin resistancea
| Parameterb | Ileal inflammation present |
Ileal inflammation absent |
Total | |||
|---|---|---|---|---|---|---|
| CD (L1+L3) | CD (L2) | UC | NI | H | ||
| Prior rifaximin treatment | Y N | Y N | Y N | Y N | Y N | |
| No. of patients with resistant E. coli/total patients | 5/6 0/13 | 2/2 0/4 | 4/4 0/9 | 0/1 0/3 | 0/0 0/8 | 11/50 |
| No. of resistant E. coli strains/total no. of strains | 6/7 0/18 | 2/2 0/7 | 4/4 0/10 | 0/1 0/3 | 0/0 0/10 | 12/62 |
a
Diagnoses: CD, Crohn's disease; L1+L3, ileal+ileocolonic; L2, colonic; UC, ulcerative colitis; NI, symptomatic non-IBD; H, healthy. Y, yes; N, no.
b
Resistance correlates with prior rifaximin treatment (P < 0.00000001) but not with the presence of ileal inflammation (P = 0.73).