Table 10.

The EC₅₀ of DBPR110-resistant variants and the binding energy of DBPR110 to HCV NS5A

Amino acid substitution(s)	DBPR110 EC50 (pM)	Binding energy (kcal/mol)a
		VDW + electrostatic	VDW contribution	Electrostatic contribution
None (parental)	1.5	−26.79	−23.63	−3.16
V153 M	1.3	−29.06	−35.16	6.10
P58L	564	−4.38	−11.08	6.70
Y93H	1,408	18.63	21.14	−2.51
Y93N	3,821	79.30	87.63	−8.33

^aVDW, van der Waals.